11 Décembre : séminaire Dominique Ferrandon

Séminaire de Dominique Ferrandon du CNRS Strasbourg, le 11 décembre 2014 à 10h45 en visio-conférence depuis le labo RIME de Montpellier

Study of resilience, a second dimension of host defense, in intestinal infections of the genetic model organism Drosophila melanogaster

KZ Lee1, M Lestradet1, S Liegeois1, S Limmer1, WM. Yamba1, C Keime2, Y Schwab2, and D Ferrandon1

1 Equipe FRM; UPR9022 du CNRS; University of Strasbourg Institute for Advanced Study
2 IGBMC, CNRS/INSERM/University of Strasbourg

Host defense is not limited to immunity and encompasses the ability to endure and repair damages and to handle toxins and toxicants. After a general introduction on the Drosophila model and the notion of resilience to infections, I will describe the existence in the flyintestine of a common response to Serratia marcescens hemolysin, a pore-forming toxin, and to xenobiotics such as caffeine, soft or heavy metals, or a strong oxidant. Exposure of enterocytes to hemolysin leads to the rapid formation of megamitochondria and a subsequent controlled extrusion of the cytoplasm along with damaged organelles, which may constitute a novel repair mechanism. This results in a thin intestinal epithelium that recovers its original shape in a few hours. The recovery process requires CyclinJ, an evolutionary conserved cyclin of hitherto unknown function. Finally, a primary exposure to toxin or xenobiotics induces cross-protection against a further hemolysin challenge, thus evoking a hormetic response, which can be elicited by ectopically expressing what else, CyclinJ-dependent gene. Thus, CyclinJ plays a central role in this novel resilience mechanism that defends the intestine against infections or intoxications

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