|IHPE UMR 5244
University of Perpignan via Domitia
52 Avenue Paul Alduy
F-66860 Perpignan Cedex FRANCE
email : email@example.com
POSITION: Ph.D student(resume french/ english)
THESIS DIRECTORS: Benjamin GOURBAL & Antonio A. VÁZQUEZ
Fasciolosis in Cuba: molecular bases of the compatibility in the Fasciola hepatica – Pseudosuccinea columella model
Lymnaeidae, Fasciola hepatica, host-parasite interaction, immunobiology
Parasite – host interaction determines an arms race in which only the reciprocal selection of compatible virulence – immunity-related genes from each part can lead to an effective transmission of the parasite. In this sense, one of the most fascinating models to study the immunobiology of the compatibility is that of trematode-mollusk interactions due to its ancient co-evolution history.
Fasciola hepatica, the main causative agent of a significant human and veterinary disease known as fasciolosis, is a digenean trematode that uses several species of freshwater mollusks from the Lymnaeidae family as intermediate host. In Cuba, the lymnaeid snail Pseudosuccinea columella acts as one of the intermediate host of the parasite. Particularly, the occurrence of two phenotypes within this specie, identified as i) susceptible and ii) naturally-resistant populations to F. hepatica infection, offers an interesting model to study the molecular bases of the compatibility of F. hepatica – lymnaeid snail interaction. To this end, the thesis project involve several approaches (e.g. proteomic, transcriptomic, ecology, biochemistry) to thoroughly characterize the phenotypes and the molecular basis of susceptibility/resistance to the parasite. The elucidation of the molecular crosstalk between F. hepatica and P. columella would enlarge our understanding of parasite – host immunobiology of this model and particularly, and for the first time, of the molecules and mechanisms involved in the natural resistance of the snails to a parasite trematode. Moreover, this knowledge might be further used to device and apply new alternatives and strategies toward the control of fasciolosis transmission.
DISTINCTIONS AND AWARDS:
– 2014, Grant of the FA3 Strategic Network on Neglected Diseases and Zoonoses for supporting junior researcher, Institute of Tropical Medicine of Antewerp, Belgium
– 2013, University of Havana Award, Cuba (co-author)
– 2012, Mention at the V International Symposium of Biochemistry and Molecular Biology
– 2010, Graduated with honors at the University of Havana, Cuba
– 2013 Master in Parasitology (Institute of Tropical Medicine « Pedro Kuri », Havana, Cuba)
– 2010 Bachelor in Biochemistry (University of Havana, Cuba)
PUBLICATIONS (before arriving at IHPE):
– Alba A, Hernández H, Marcet R, Vázquez AA, Figueredo M, Sánchez J, Otero O, Sarracent J. A novel double monoclonal antibody based-immunoenzymatic assay for epidemiological surveillance of the vector snails of Fasciola hepatica (Trematoda: Digenea). International Journal for Parasitology. 2015; 45: 113-119.
– Alba A, Vázquez AA, Hernández H, Sánchez J, Marcet R, Figueredo M, Sarracent J, Fraga J. A multiplex PCR for the detection of Fasciola hepatica in the intermediate snail host Galba cubensis. Veterinary Parasitology. 2015; 211: 195-200.
– López-Abarrategui C, Otero-González AJ, Alba-Menéndez A, Reguera-Ruiz E, Franco OL. 2015. Nanoparticles as a promise for host defense peptides therapeutics. In Biological and pharmaceutical applications of nanomaterial, (Ed) Prokopovich P. CRC Press, Taylor and Francis Group, London, 129-148 pp.
-Vázquez AA, Sánchez J, Alba A, Pointier JP, Hurtrez-Boussès S. Natural prevalence in Cuban populations of the lymnaeid snail Galba cubensis infected with the liver fluke Fasciola hepatica: small values do matter. Parasitology Research. 2015; 114 (11): 4205-10.
– Martínez E, Sánchez J, Alba A, Vázquez A. Changes in structure and composition of two communities of rocky shores molluscs exposed to different human impact in Playa Jibacoa, Cuba. Journal of Ecosystems & Ecography; 2015; 5: 162.
– Vázquez AA, Lounnas M, Sánchez J, Alba A, Milesi A, Hurtrez-Boussès, S. Genetic and infective diversity of the liver fluke Fasciola hepatica (Trematoda: Digenea) from Cuba. Journal of Helminthology, 2015; doi: 1017/S0022149X15001029.
– López-Abarrategui C, McBeth C, Mandal SM, Zhen-Yu JS, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, Dias SC, Brandt W, Wessjohann LA, Stanbarch M, Otero-González AJ, Franco O. Cm-p5, an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J. 2015; doi. 10.1096/fj.14.269860.
-Alba A, Hernández H, Marcet R, Gil AE, Vázquez AA, Figueredo M, Sánchez J, Garay HE, Sarracent J. Exploring the antigenic features of Fasciola hepatica (Trematoda: Digenea) rediae through the evaluation of three different antigenic candidates for further monoclonal antibody development. Parasitology Research. 2014; 113(9):3185-93.
– Vázquez AA, Sanchez J, Alba A, Rodríguez E, Pino A. [First report of natural infection of Galba cubensis (Mollusca: Gastropoda: Lymnaeidae) with Paramphistomidae (Trematoda: Digenea) larvae in Cuba] (article in Spanish). Revista Cubana de Medicina Tropical. 2013; 65(3): 394-397.
– Alba A, Lopéz-Abarrategui C, Otero-González AJ. Host defense peptides: an alternative as antiinfective and immunomodulatory therapeutics. Biopolymers (Peptide Science). 2012; 98: 251–267.
– López-Abarrategui C, Alba-Menéndez A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva RM, Garay HE, Dias SC, Franco OL, Otero-González AJ. Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus. Biochimie. 2012; 94: 968-974.
– López-Abarrategui C, Alba-Menéndez A, Nascimento O, Reyes Acosta O, Vasconcelos I, Oliveira J, Migliolo L, Garay HE, Campos Dias S, Franco OL, Otero-González AJ. Screening of antimicrobials from Caribbean sea animals and isolation of bactericidal proteins from the littoral mollusk Cenchritis muricatus. Current Microbiology. 2012; 64(5): 501-5.
– Vázquez AA, García C, Sánchez J, Alba A. Distribución y características ecológicas de los moluscos fluviales de importancia médica en la provincia Santiago de Cuba. Revista Cubana de Medicina Tropical. 2011; 63(1): 58-63.