IHPE – GAWRA Janan english

JananIHPE UMR 5244
Université de Montpellier
Place Eugène Bataillon CC 80
F-34095 Montpellier Cedex 5
Tel +33(0)4-67-14-37-26
Fax +33(0)4-67-14-46-22
email : janan.khamo@gmail.com
POSITION:Ph.D student (download resume)
THESIS DIRECTORS: Christoph GRUNAU, Jérémie VIDAL-DUPIOL, Jean-Baptiste LAMY
TEAM: ECOEVI
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THESIS SUBJECT:>Integrative approach of the resistance mechanisms to the mass mortality syndrome affecting the juvenile of the oyster Crassostrea gigas (POMS)
KEYWORDS:
Genetic/epigenetic,  resistance/susceptibility, host/pathogen, epizooty, virus, oyster
THESIS PROJECT:
Marine molluscs are essentially important food supply source. Along with the increase of the human population the demand for food is increasing as well.  Within the scope of aquaculture intensification and globalization, epidemics have strongly affected the production of many aquaculture industries. The most important oyster species exploited in the world, Crassostrea gigas,  is no exception from this crisis. Since 2008, massive mortality events of juvenile oysters of this species have dramatically threatened the oyster aquaculture industry. In France in 2016, the mortality rate reached up to 65% of the total number of spat harvested. This disease called massive mortality syndrome is of complex aetiology. A large number of studies have shown that a combination of agents, including herpes virus (OsHV-1 μVar) and opportunistic populations of Vibrios of the splendid clade are responsible for the disease. Different studies highlight that the resistance of oysters to OsHV-1 μVar is based on an overlapping of mechanisms that remain to be elucidated. More generally, a series of studies dedicated to host/pathogen interactions in a wide variety of phyla have shown that the genetics of the host and the pathogen, although essential, are not the only actors in the compatibility between the two partners. Indeed, many studies showed that the epigenotype in particular should be taken into account as an engineer of phenotypic variation. It is therefore necessary to consider genotypes and epigenotypes as a material on which selection can act to shape a phenotype that could be transmitted (at least in part) to the offspring. Unfortunately, holistic approaches integrating these two components (genetic and epigenetic) remain rare. In this study, our main goal is to identify the genetic and epigenetic markers associated with resistance. Our study is first of its kind to study the epigenetic markers associated with resistance.