IHPE – HAMMEL Maurine English

MaurineIHPE UMR 5244
University of Montpellier
Place Eugène Bataillon CC 80
F-34095 Montpellier Cedex 5 FRANCE
Tel +33(0)4-67-14-37-26
Fax +33(0)4-67-14-46-22
email: Maurine.Hammel@partenaire-exterieur.ifremer.fr
POSITION : Ph.D student
THESIS DIRECTORS : Guillaume Charrière (IHPE) & Nicolas Bierne (ISEM)
TEAM : MIMM
THESIS SUBJECT :
Cellular and Evolutinary biology of the blue mussel transmissible cancer
KEYWORDS :
Interactions biology, Disseminated Neoplasia, Evolution and Ecology, Genomics, Marine biology, Organisms biology   
THESIS PROJECT :
Cancer is usually an evolutionary dead end : a selfish cell line appears and thrives at the expense of the multicellular host from which it is derived, causing the death of its host as well as its own. In recent years, transmissible cancers have been described in different animal species. In these cases, cancer cell lines have managed to escape this evolutionary impasse by having acquired the ability to be transmitted between individuals. Hence, these cancerous lines have become true independent pathogens, perpetuating the cancer process for much longer times than the life of their original host. Transmissible cancers are considered very rare in vertebrates with only two examples that are known to date (in dogs and Tasmanian devils). Recent work indicates that transmissible cancers may be more common in invertebrates, particularly bivalve molluscs. However we still know very little about these transmissible cancers that have been ignored for so long: How and why do they emerge? At what pace? How long do they evolve? What are their ecological and evolutionary consequences on natural populations? Hence these cancers raise many fundamental questions about the biology of cancers and their interactions with their hosts. The proposed thesis project is rooted in the framework of the BLUECANCER project, supported by a multi-disciplinary Montpellier team combining skills in cell biology, immunology and evolutionary genomics, focuses on the study of newly discovered transmissible cancer in the three species of blue mussel. (Mytilus spp.).
The main objectives are
1- Study the invasive properties of cancer cells and the response of invaded hosts.
2- Infer the evolutionary history of transmissible cancer by the analysis of genomic sequences of tumors and their hosts
TEACHING
2019 : University of Montpellier, First year cursus, Directed work in « life cycle » & 2cd year cursus, Practical work in «Diversity of current and fossil plants »
RESUME
2018-present : PhD in Cellular and Evolutionary Biology (Université Montpellier, in IHPE and ISEM)
2016-2018 : Master in Biodiversity, Ecology and Evolution – Evolutionary Biology and Ecology Darwin (Université Montpellier)
2012-2013 : Bachelor in Ecology, Organisms Biology (Université Montpellier)
PUBLICATIONS