IHPE – LAFONT Maxime english

Maxime-2017IHPE UMR 5244
University of Montpellier
Place Eugène Bataillon CC 80
F-34095 Montpellier Cedex 5 FRANCE
Tel +33(0)4-67-14-37-26
Fax +33(0)4-67-14-46-22
email: maxime.lafont@partenaire-exterieur.ifremer.fr
POSITION : Ph.D Student (Download resume)
THESIS DIRECTORS : Benjamin GOURBAL & Caroline MONTAGNANI
TEAM: MIMM
SCIENTIFIC SOCIAL NETWORKS : (click on the logo)
THESIS SUBJECT :
Mechanism and specificity of immune priming in lophotrochozoan molluscs
KEY WORDS :
Host-pathogen interractions, Crassostrea gigas, Mortalités estivales, OsHV-1 (ostreid herpes virus 1), Biomphalaria glabrata, Bilharzia, Schistosoma mansoni, Immune priming, RNA-seq, RNAi, Cellular and molecular mecanisms
THESIS PROJECT :
Preventive protection of invertebrates against infections (vaccination) has long been considered impossible since they are, unlike vertebrates, devoid of memory cells able to clonally produce specific immunoglobulins. However, in recent years, specific recognition mechanisms have been identified in invertebrates and the question of the existence of a form of immune memory was raised. These mechanisms have been associated with the term « immune priming ». This thesis project will raise the issue of the conservation of the molecular basis (mechanism and specificity) of immune priming in molluscs Lophotrochozoa. It will focus on two key models for their phylogenetic position (bivalve and gastropod) as well as economic interest (oyster Crassostrea gigas) and medical interest (Biomphalaria glabrata, vector of human Bilharzia or schistosomiasis) . Based on recent laboratory results, the thesis project will (i) identify the molecular basis of immune priming phenomena by a whole transcriptome shotgun sequencing method (RNAseq) and (ii) analyze the function of genes identified using gene knockdown (RNAi). The study of these two models provides an opportunity to discover new and unconventional immune mechanisms and pathways as compared to vertebrate immunity. The characterization of the molecular basis of immune priming will also provide new clues to help the protection of oysters threatened by massive summer mortalities or regarding epidemiological issues in the control of Bilharzia.
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