IHPE – LAGORCE Arnaud English

ArnaudIHPE UMR 5244
University of Perpignan via Domitia
52 Avenue Paul Alduy
F-66860 Perpignan Cedex FRANCE
Tel +33(0)4-
Fax +33(0)4-68-66-22-81
email: arnaud.lagorce@univ-perp.fr
 POSITION: Assistant Professor, University of Perpignan Via Domitia
I’m a microbiologist that used to work on model microorganisms (prokaryotes and eukaryotes) using genome-wide approaches (transcriptome, proteome, sequençing) to unravel fundamental or applied questions. At the Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (INSA Toulouse), I characterized yeast cell wall mutants through biochemical and genomics approaches (EuroCellWall European project). Fungi cell wall being a target of interest for fungicide development, I worked a couple of years for Bayer CropScience to explore the infection cycle of the rice phytopathogenic fungi Magnaporthe oryzae with the aim to identify potential new targets (Garnish European project).  In 2005, I moved to Paris-Sud University to investigate the cellular and transcriptomics responses to heavy metals and radiation in the model archaea Thermococcus gammatolerans (CEA ToxNuc-E and ANR Gammatolerans projects). I finally joined in 2016 the Interactions-Hôtes-Pathogènes-Environnements (IHPE) laboratory to study the etiology of summer mortalities observed in the oyster Crassostrea gigas. My current research projects deal with the characterization of the vibrio populations associated with oysters and their involvement in summer mortalities in the Mediterranean sea (ANR Decipher and PEPS Inhospitality projects).
2005 : Lecturer position – Paris-Sud University.
2002 : PhD in Biology – Health – Biotechnologies – INSA de Toulouse.
1999 : Post Graduate Degree in Biology – Health – Biotechnologies – INSA de Toulouse.
1995-1999 : Bachelor and Master degree in Cellular Biology and Physiology – University of Bordeaux.
- Microbiology
– Molecular biology
– Genomics
LAST PUBLICATIONS before this lab
Barbier E, Lagorce A, Hachemi A, Dutertre M, Gorlas A, Morand L, Saint-Pierre C, Ravanat JL, Douki T, Armengaud J, Gasparutto D, Confalonieri F, Breton J. Oxidative DNA Damage and Repair in the Radioresistant Archaeon Thermococcus gammatolerans. Chem Res Toxicol. 2016.
 Yang YS, Fernandez B, Lagorce A, Aloin V, Montet De Guillen K, Boyer JB, Dedieu A, Confalonieri F, Armengaud J, Roumestand C. Prioritizing targets for structural biology through the lens of proteogenomics: TGAM_1934, an archaeal, frataxin-like protein. Proteomics. 2015.
 Klaubauf S, Ribot C, Melayah D, Lagorce A, Lebrun MH, de Vries RP. The pentose pathway of the rice-blast fungus Magnaporthe oryzae involves a novel pentose reductase restricted to few fungal species. FEBS Lett. 2013.
 Lagorce A, Fourçans A, Dutertre M, Bouyssière B, Forterre P, Zivanovic Y and Confalonieri F. Genome-wide transcriptional response of the archaeon Thermococcus gammatolerans to cadmium. PLOS One. 2012.
 Zivanovic Y, Armengaud J, Lagorce A, Leplat C, Guérin P, Dutertre M, Anthouard V, Forterre P, Wincker P and Confalonieri F. Genome analysis and genome-wide proteomics of T. gammatolerans, the most radioresistant organism known amongst Archaea. Genome Biology. 2009.
 Hagen I, Ecker M, Lagorce A, Francois JM, Sestak S, Rachel R, Grossmann G, Hauser NC, Hoheisel JD, Tanner W, Strahl S. Sed1p and Srl1p are required to compensate for cell wall instability in S. cerevisiae mutants in multiple GPI-anchored mannoproteins. Mol Microbiol. 2004.
 Martin-Yken H, Dagkessamanskaia A, Basmaji F, Lagorce A, Francois J. The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol Microbiol. 2003.
 Lagorce A, Hauser NC, Labourdette D, Rodriguez C, Martin-Yken H, Arroyo J, Hoheisel JD, Francois J. Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem. 2003.
 Lagorce A, Le Berre-Anton V, Aguilar-Uscanga B, Martin-Yken H, Dagkessamanskaia A, Francois J. Involvement of GFA1, which encodes GF6P amidotransferase, in the activation of the chitin synthesis pathway in response to cell-wall defects in S. cerevisiae. Eur J Biochem. 2002.
 Martin-Yken H, Lagorce A, François J. The yeast S. cerevisiae cell wall : Molecular architecture, regulatory pathways, remodeling mechanism in response to environmental conditions, and biotechnological values, Recent Res. Devel. in Microbiology, 6, 503-526, ISBN:817736-145-7, 2003