IHPE – LASICA Chrystelle English

chrystelleIHPE UMR 5244
University of Perpignan via Domitia
52 Avenue Paul Alduy
F-66860 Perpignan Cedex FRANCE
Tel +33(0)4-68-66-20-50
Fax +33(0)4-68-66-22-81
email : chrystelle.lasica@univ-perp.fr
POSITION: Ph.D student
THESIS DIRECTORS: Hélène Moné
TEAM: ECOEVI
THESIS SUBJECT:
Control of Schistosoma circadian rhythm, human parasite at the gate of Occitania (France)
KEY WORDS:
Chronobiology, Schistosoma mansoni, genetic, epigenetic, transcriptomic
THESIS PROJECT:
The aim of the project is to analyse the chronobiology of cercarial emission in Schistosoma life cycle, to understand factors which are involved in the parasite transmission and which are essential for public health community and evolutionary biology research.
The project will be developed according to four objectives:
Objective 1 will use epigenomic tools to identify genome region and candidate gene during circadian rhythm of cercarial emission. We already found acetylation differences for two positions of histone amino acids H3 (H3K9 and H3K14) in 107 genomic regions for nocturnal strain between emission peak and period without emission.
Objective 2 will use RNAseq experiment to examine expression rhythm of nocturnal and diurnal parasite genes through 12H light/ 12H night cycles, and to study metabolic path which are involved in cercarial emission.
Objective 3 will use our genomic advanced results to test their application on other strains and species, in particular Corsica ones.
Objectif 4 will be to establish a robust set of circadian rhythm markers in Schistosoma based on the results obtained from objectives 1-3 to provide rapid and effective control in emerging areas of the disease. This will make it possible to define appropriate recommendations to organize and minimize aquatic contacts with infecting larvae in these regions.
RESUME:
2018- : Ph.D
2017 : Master degree in « Interaction Microorganismes Hôtes Environnement » at University of Montpellier (UM)
2015 : Bachelor’s degree in Biology speciality microbiology at University of Montpellier (UM)
2011-2012 : PACES (1st year health studies) at pharmacy faculty of Montpellier
2010 : High-School Degree in Science of life and Earth, at Notre Dame de La Merci High school (Montpellier)