IHPE- LASSALLE Damien english

Damien2IHPE UMR 5244
University of Perpignan via Domitia
52 Avenue Paul Alduy
F-66860 Perpignan Cedex FRANCE
Tel +33(0)4-68-66-20-50
Fax +33(0)4-68-66-22-81
email : damien.lassalle@univ-perp.fr
POSITION : Ph.D student
THESIS DIRECTORS : Benjamin GOURBAL & David DUVAL
TEAM : ECOEVI
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THESIS TITLE :
Mechanism of action of Biomphalysines, new therapeutic targets against bilharziasis?
KEY WORDS :
Bilharziosis ; Biomphalysin ; Toxin ; Schistosoma mansoni ; Biomphalaria glabrata
THESIS PROJECTS :
Bilharzia is a disease affecting 230 million people worldwide (WHO source). This parasitosis is caused by schistosome, a parasitic flat worm, and in particular by Schistosoma mansoni, responsible for intestinal schistosomiasis in Africa and tropical America. Before entering the human body through the skin, this parasite develops in a freshwater snail, Biomphalaria glabrata, which serves as an intermediate host. The Pathogenic Environments Hosting Interactions team from the University of Perpignan has identified for the first time a toxin produced by this mollusc and capable of killing the parasite. We characterized more than twenty genes related to the biomphalysine family. These proteins constitute a family in their own right which from a structural point of view are very close. This thesis will therefore propose to study the role of these different biomphalysines in the context of the interaction between the host and its parasite in order to identify new strategies for fighting and controlling the disease in the field. But this work will also make it possible to study the role of these molecules on other pathogens or pathologies. Indeed, some of these proteins are able to bind to different bacteria, yeast or other parasitic worms of the genus Echinostoma. Their antibacterial, antifungal or antiparasitic activities will therefore be tested. Finally, certain bacterial toxins belonging to this same family are capable of killing tumor cell lines such as HeLa or HEK cells. Since biomphalysians share structural similarities with these toxins, we will also test the anti-tumor activity of biomphalysines on different tumor cell lines and thus exploit these immune defense molecules as a new source of drug candidates.
RESUME:
2017-  Graduation in engineering of biotechnology
2017 – Master Interaction hôsts pathogens environments, University of Montpellier
2014- Deug Biology and ecology
PUBLICATION IN THE LAB: link