IHPE – LUCASSON Aude english *
POSITION IN THE LAB: Ph.D student 2015-2018 (Download resume)
THESIS DIRECTORS: Julien DE LORGERIL & Guillaume MITTA
SCIENTIFIC SOCIAL NETWORKS:
HAL id or cv
Holobionte dynamics during pathogenesis in the Pacific oyster Crassostrea gigas
Meta-organism ; holobiont ; pathosystem ; multifactorial diseases ; transcriptome ; microbiote structure
Since a few years, mass and recurrent mortality events of complex etiology have increasingly affected invertebrates of ecological and/or economical interest. The main oyster species exploited, Crassostrea gigas, suffers from devastating mortality outbreaks resulting in significant economic losses. A series of research projects have evidenced several factors with potential interactions are involved in the expression of the disease: (i) the temperature of the seawater potentially modifying both host physiology (reproductive capacities, health) and composition/function of its associated microbiota (including pathogen virulence); (ii) the susceptibility of oysters to potential pathogens (herpes viruses, bacteria such as Vibrio splendidus, V. aestuarianus,) that depends on the genetic background of oysters; (iii) the pathogenic microorganisms cooperation to initiate pathogenesis; and (iv) the production sites. However, the relative weight of these factors, their interactions, their dynamics during pathogenesis are largely unknown, making the disease difficult to understand, predict and control. To open a way out of this unprecedented crisis and find solutions for a sustainable oyster aquaculture, it is necessary to decipher this complex pathosystem. This thesis project will contribute to an integrated multidisciplinary research program in an attempt to link together different levels of understanding of the disease. It will focus on the dynamic study of the ‘oyster holobiont’ (oyster and associated microbiota) and will integrate in a global picture the genetic background of the host, changes in the environment and the history of interactions between the protagonists of this pathosystem. The results of the thesis should bring (i) a clear answer to the question of summer mortalities affecting oyster and (ii) solutions to improve the eco-efficiency of oyster culture and contribute to the sustainability of this industry.
2015-present Ph.D Student, University of Montpellier, France.
2014-2015 Tutoring with associations. Montpellier, France.
2012-2014 MSc Marine Biology with honours, best student of the class. European Universitary Institute of the Sea (IUEM).
2008-2012 BSc Microbiology. University Biology with honours. University of Montpellier, France.
PUBLICATIONS IN THE LAB: link
PUBLICATIONS OUT OF THE LAB:
– Mai T., Tintillier F., Lucasson A., Moriou C., Bonno E., Petek S., Magré K., Al Mourabit A., Saulnier D., Debitus C. (2015) Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863. Lett. Appl. Microbiol. Oct;61(4):311-7. doi: 10.1111/lam.12461. Epub 2015 Aug 14.