IHPE – Transversal Epigenetics
« Relative weight of genetics and epigenetics in adaptative evolution »
Head Christoph GRUNAU
Since the discovery of the DNA, it is generally assumed that this carrier of the genetic information is the only source of heritable phenotypic variants. However, during the last couple of years, epigenetics, i.e. heritable information on the status of gene expression without changes in the DNA sequence has emerged as a new source of phenotypic variation. With the advancements in next-generation sequencing technologies, whole-genome genetic and epigenetic studies are now accessible for so called non-model organisms. We believe that including epigenetic information into the theory of evolution will largely improve our understanding and control of adaptation.
Today’s challenge is not anymore to answer the question if or if not epigenetic and genetic information contribute the generation of heritable phenotypic variants, on which selection can act. Instead, it is now necessary to determine the relative importance of both systems in different biological systems.
CURRENT COLLABORATIVE PROJECTS
– Transgenerationa effects of Diuron on the Oyster Crassostrea gigas (MIMM-BMC)
– Chromatin structure and sex in Schistosoma mansoni (2EIHP-BMC)
Funded projects in 2015
– GenEpi 01/2015- Genetic and epigenetic effects of host change on Schistosoma mansoni clones (PI: Roquis D.)
– GenEpi 02/2015- Study of BgMiRNAs (PI: Duval D.)
– GenEpi 03/2015 – Comparative epigenomics of Schistosoma mansoni strains with different chronotypes (PI: Moné H. & Mouahid G.)
RTP 3E Epigénétique en Ecologie et Evolution: http://rtp-3e.wix.com/rt3e