 | IHPE UMR 5244 Université de Perpignan via Domitia 52 Avenue Paul Alduy F-66860 Perpignan Cedex Tel +33(0)4-68-08-18-13 Fax +33(0)4-68-66-22-81 email : annia.alba@gmail.com |
GRADE : post-doctorante UPVD (Bourse MOPGA)
EQUIPE : 2MAP
CV à télécharger (pdf)
RESEAUX SOCIAUX SCIENTIFIQUES :
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DOMAINE D’EXPERTISE :
Je suis intéressée par l’étude des maladies infectieuses, l’écologie parasitaire, l’épidémiologie et les interactions hôte-parasite à différents niveaux : moléculaire, cellulaire, immunologique, écologique et évolutif. La majeure partie de ma recherche a été focalisée sur Fasciola hepatica, à savoir : la surveillance de sa transmission –particulièrement par le développement de nouveaux outils de détection (PCR et ELISAs)–, son contrôle et son interaction avec ses hôtes. J’ai collaboré sur d’autres projets concernant des autres parasites e.g. Leishmania, T. vaginalis, A. cantonensis, paramphistomids, trématodes de la faune sauvage. En plus, j’ai été impliquée dans la caractérisation des peptides antimicrobiens pour développer des nouvelles variantes antibiotiques. J’ai un large nombre des compétences en laboratoire (e.g. de la purification des protéines, de la génération /caractérisation des AcM, de développement des méthodes diagnostiques, et de la biologie cellulaire et moléculaire (y compris des ‘omiques’), et des compétences pour des études expérimentales en utilisant des modèles biologiques, de la bio-informatique et du travail du terrain
PRIX, DISTINCTIONS:
2021- Membre du Comité Scientifique de l’Institut Pedro Kouri de Médecine Tropicale
2018-2024 Membre jeune de l’Académie des Sciences de Cuba
2017 Prix annuel de l’Académie des Sciences de Cuba
2016 Prix National en Sciences de la Santé accordé par le Ministère de la Santé à Cuba
2012 Poster “Etudes sur des candidates antigeniques pour developer des anticorps monoclonaux comme reactives immunologiques pour des méthodes diagnostiques ” primé au 5th International Symposium of Biochemistry and Molecular Biology
CURSUS :
2022-2023 Chercheuse post-doctorante Bourse MOPGA (IHPE, Perpignan France)
2021-2022 Chercheuse CDI (Instituto Pedro Kouri Cuba)
2020 Chercheuse post-doctorante SPE (Université de Corse France)
2015-2018 Doctorat Sciences Biologiques (Université de Perpignan France / Institut Pedro Kouri Cuba)
2013-2016 Doctorat en Sciences de la Santé (Institut Pedro Kouri Cuba)
2011-2013 Master en Parasitologie (Universidad la Havane, Cuba)
2005-2010 Licence “summa cum laude” en Sciences Biochimie (Universidad la Havane, Cuba)
PUBLICATIONS HORS IHPE :
1. Alba A*, Vázquez AA, Sanchez J, Gourbal B*. Immunological resistance of Pseudosuccinea columella snails from Cuba to Fasciola hepatica (Trematoda) infection: what we know and where we go on comparative molecular and mechanistic immunobiology, ecology and evolution. Front Immunol. 2022
2. Vázquez AA, Alba A, Alda P, Vittecoq M, Hurtrez-Boussès S. On the arrival of fasciolosis in the Americas. Trends Parasitol. 2022
3. Alba A*, Vázquez AA, Hurtrez-Boussés S. Towards the comprehension of fasciolosis re-emergence: an integrative overview. Parasitology. 2021
4. Raber H, Sejfijaj J, Kissmann AK, Wittgens A, Gonzalez-Garcia M, Alba A, Vázquez AA, Morales-Vicente F, Pérez Erbiti J, Kubiczek D, Kubiczek D, Otero-González A, Rodriguez A, Ständker L, Rosenau F. Antimicrobial peptides Pom-1 and Pom-2 from Pomacea poeyana are active against Candida auris, C. parasilopsis and C. albicans biofilms. Pathogens. 2021
5. Vázquez AA, Sabourin E, Alda P, Leroy C, Carron E, Mulero S, Saugné L, Pineau O, Blanchon T, Alba A, D., Vittecoq M, Hurtrez-Boussès S. Genetic diversity and relationships of the liver fluke Fasciola hepatica (Trematoda) with native and introduced definitive and intermediate hosts. Transbound Emerg Dis. 2021
6. Alba A*, Duval D, Sánchez J, Pérez AB, Pinaud S, Galiner R, Vázquez AA, Gourbal B*. The immunobiological interplay between Pseudosuccinea columella resistant/susceptible snails with Fasciola hepatica: hemocytes in the spotlight. Dev Comp Immunol.
7. Montalvo AM, Alba A, Fraga J, Marzoa AP, Torres C, Muskus C. Improving the sensitivity of an hsp20-based PCR for genus detection of Leishmania parasites in cutaneous clinical samples: a proof of concept. Parasitol Res. 2020
8. González-García M, Rodríguez A, Alba A, Vázquez AA, Morales-Vicente F, Pérez Erbiti J, Spellerberg B, Stenger S, Greishober M, Conzelman C, Munch J, Raber H, Kubiczek D, Rosenau F, Wiese S, Staendker L, Otero-González A. New antibacterial peptides from the freshwater mollusk Pomacea poeyana (Pilsbry, 1927). Biomolecules. 2020
9. Alba A1, Vázquez AA1, Sánchez J, Lounnas M, Pointier JP, Hurtrez-Boussès S, Gourbal B. Patterns of distribution, population genetics and ecological requirements of field-occurring resistant and susceptible Pseudosuccinea columella snails to Fasciola hepatica in Cuba. Sci Rep. 2019 (1equal contributors)
10. Alba A*, Tetreau G, Chaparro C, Sánchez J, Vázquez AA, Gourbal B*. Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: a review from literature and insights from comparative “omics” analyses. Dev Comp Immunol. 2019
11. Vázquez AA, Vargas M, Alba A, Sánchez J, Alda P, Sabourin E, Vittecoq M, Martínez J, Alarcón-Elbal P, Pointier JP, Hurtrez-Boussès S. Reviewing Fasciola hepatica transmission in the West Indies and novel perceptions from experimental infections of sympatric vs. allopatric snail/fluke combinations. Vet Parasitol. 2019
12. Hernández H, Fraga J, Marcet R, Alba A, Figueredo M, Rojas L, Alfonso Y, Sarracent J. Genetic diversity of Trichomonas vaginalis clinical isolates according to Restriction Fragment Length Polymorphism analysis of the 60 kDa proteinase gene. Acta Parasitol. 2019
13. Alba A, Vázquez AA, Sánchez J, Duval D, Hernández H, Sabourin E, Vittecoq M, Hurtrez-Boussés S, Gourbal B. Fasciola hepatica – Pseudosuccinea columella interaction: effect of increasing parasite doses, successive exposures and geographical origin on the infection outcome of naturally-resistant and susceptible snails from Cuba. Parasites Vect. 2018
14. Sánchez J, Alba A, García E, Cantillo J, Castro R, de la Cruz TM, Vázquez AA. Detected trematodes inside blue-winged teals (Spatula discors) give insights on north-south flow of parasites through Cuba during migration. Vet Parasitol. 2018
15. Vázquez AA, Sánchez J, Alba A, Martínez E, Alvarez-Lajonchere L, Matamoros M, Coupland J. Updated distribution and experimental life-history traits of the recently introduced vector snail Lissachatina fulica in Cuba. Acta Trop. 2018
16. Montalvo A.M., Fraga J, Álvarez L, Alba A, Torres C. Normalización de una nueva variante de reacción en cadena de la polimerasa-hsp 20 (PCR-hsp20S) útil para la detección de Leishmania. Rev Cubana Med Trop. 2018
17. Vázquez AA, Alda P, Lounnas M, Sabourin E, Alba A, Pointier JP, Hurtrez-Boussès S. Lymnaeid snails hosts of Fasciola hepatica and Fasciola gigantica (Trematoda: Digenea): a worldwide review. CAB Reviews. 2018
18. González-García M, Valdés ME, Freitas CG, Alba A, López-Abarrategui C, San Juan J, Campos-Diaz S, Franco OL, Otero-González AJ. Actividad biológica complementaria in vitro del péptido antifúngico Cm-p5 y predicción in silico de sus regiones funcionales. Rev Cubana Med Trop. 2017
19. Vázquez AA, Sánchez J, Martínez E, Alba A. Facilitated invasion of an overseas invader: human mediated settlement and expansion of the giant African snail Lissachatina fulica in Cuba. Biol Invasions. 2017
20. Montalvo AM, Fraga J, Tirado D, Blandón G, Alba A, Van der Auwera G, Vélez ID, Muskus C. Detection and identification of Leishmania spp.: application of two hsp70-based PCR-RFLP protocols to clinical samples from the New World. Parasitol Res. 2017
21. Alba A*, Vázquez A, Sánchez J, Fraga J, Martínez E, Hernández H, Marcet R, Figueredo M, Sarracent J. Assessment of the FasciMol-ELISA in the detection of the trematode Fasciola hepatica in field-collected Galba cubensis: a novel tool for the malacological survey of fasciolosis transmission. Parasites Vect. 2016
22. Alba A*, Sánchez J, Hernández H, Mosqueda M, Rodríguez SY, Capó V, Alfonso C, Marcet R, Figueredo M, Sarracent J. Insight into the biological features of the antigenic determinants recognized by four monoclonal antibodies in rediae and adult stages of the liver fluke Fasciola hepatica. Exp Parasitol. 2016
23. Alba A*, Marcet R, Otero O, Hernández H, Figueredo M, Sarracent J. Isolation of 1E4 IgM anti-Fasciola hepatica rediae monoclonal antibody from ascites: comparison of two purification protocols. Monocl Antib Immunodiag Immunother.2016
24. Vázquez AA, Lounnas M, Sánchez J, Alba A, Milesi A, Hurtrez-Boussès, S. Genetic and infective diversity of the liver fluke Fasciola hepatica (Trematoda: Digenea) from Cuba. J Helminthol. 2016
25. Alba A*, Hernández H, Marcet R, Vázquez AA, Figueredo M, Sánchez J, Otero O, Sarracent J. A novel double monoclonal antibody based-immunoenzymatic assay for epidemiological surveillance of the vector snails of Fasciola hepatica (Trematoda: Digenea). Int J Parasitol. 2015
26. Alba A, Vázquez AA, Hernández H, Sánchez J, Marcet R, Figueredo M, Sarracent J, Fraga J. A multiplex PCR for the detection of Fasciola hepatica in the intermediate snail host Galba cubensis. Vet Parasitol. 2015
27. Vázquez AA, Sánchez J, Alba A, Pointier JP, Hurtrez-Boussès S. Natural prevalence in Cuban populations of the lymnaeid snail Galba cubensis infected with the liver fluke Fasciola hepatica: small values do matter. Parasitol Res. 2015
28. Martínez E, Sánchez J, Alba A, Vázquez A. Changes in structure and composition of two communities of rocky shores molluscs exposed to different human impact in Playa Jibacoa, Cuba. J Ecosyst Ecogr. 2015
29. López-Abarrategui C, McBeth C, Mandal SM, Zhen-Yu JS, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, Dias SC, Brandt W, Wessjohann LA, Stanbarch M, Otero-González AJ, Franco O. Cm-p5, an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J. 2015
30. Alba A*, Hernández H, Marcet R, Gil AE, Vázquez AA, Figueredo M, Sánchez J, Garay HE, Sarracent J. Exploring the antigenic features of Fasciola hepatica (Trematoda: Digenea) rediae through the evaluation of three different antigenic candidates for further monoclonal antibody development. Parasitol Res. 2014
31. Vázquez AA, Sánchez J, Alba A, Rodríguez E, Pino A. Primer reporte de infección natural de Galba cubensis (Mollusca: Gastropoda: Lymnaeidae) con larvas de Paramphistomidae (Trematoda: Digenea) en Cuba. Rev Cubana Med Trop. 2013
32. Alba A, Lopéz-Abarrategui C, Otero-González AJ. Host defense peptides: an alternative as antiinfective and immunomodulatory therapeutics. Biopolymers (Pept Sci). 2012
33. López-Abarrategui C, Alba-Menéndez A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva RM, Garay HE, Dias SC, Franco OL, Otero-González AJ. Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus. Biochimie. 2012
34. López-Abarrategui C, Alba-Menéndez A, Nascimento O, Reyes Acosta O, Vasconcelos I, Oliveira J, Migliolo L, Garay HE, Campos Dias S, Franco OL, Otero-González AJ. Screening of antimicrobials from Caribbean Sea animals and isolation of bactericidal proteins from the littoral mollusk Cenchritis muricatus. Cur Microbiol. 2012
35. Alba Menéndez A, López C, Vázquez AA, Otero AJ. Optimización de la solución de extracción de moléculas antibacterianas de Cenchritis muricatus (Gastropoda: Littorinidae). Rev Cubana Med Trop. 2011
36. Vázquez AA, García C, Sánchez J, Alba A. Distribución y características ecológicas de los moluscos fluviales de importancia médica en la provincia Santiago de Cuba. Rev Cubana Med Trop. 2011